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Welcome to the P.R.I.S.M., a web-server that can be used to explore protein interfaces and predict protein-protein interactions. Protein Interfaces Proteins associate through binding sites. These sites are believed to contribute to the biomolecular recognition and binding of proteins by providing specific chemical and physical properties necessary for these processes. Many of the residues on interfaces that are critical for binding are also likely to be evolutionarily conserved. [Learn More...]Interface Dataset [View] All interfaces between two protein chains obtained from higher complexes of proteins available in PDB were extracted. As a result, 21,684 two-chain interfaces were obtained. Interfaces sharing similar architectures were grouped into clusters, resulting in 3,799 interface clusters. Each cluster includes a representative interface structure and members similar to the representative interface.Template Interface Dataset [View] The template dataset represents the entirety of structurally available protein-protein interactions and serves as a template to predict other potentially interacting protein pairs. It is a non-redundant, structural and evolutionary representative set of all protein-protein interactions listed in the PDB database. [Learn More...]Target Structure Dataset [View] This dataset is a sequentially non-redundant subset (with a sequence identity upper limit of 50%) of all the polypeptide chains and complexes existing in the PDB. Every pair of member structures in this dataset is checked for potential interactions. [Learn More...]Predictions [View] The algorithm used for protein-protein interaction prediction principally seeks for pairs of polypeptide chains that may potentially interact in our target dataset by comparing them with our template interfaces. [Learn More...] |
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